From Lineage to Wiring Specificity
نویسندگان
چکیده
منابع مشابه
From Lineage to Wiring Specificity POU Domain Transcription Factors Control Precise Connections of Drosophila Olfactory Projection Neurons
Axonal selection of synaptic partners is generally believed to determine wiring specificity in the nervous system. However, we have recently found evidence for specific dendritic targeting in the olfactory system of Drosophila: second order olfactory neurons (Projection Neurons) from the anterodorsal (adPN) and lateral (lPN) lineages send their dendrites to stereotypical, intercalating but non-...
متن کاملDevelopment of wiring specificity in the olfactory system.
The olfactory system discriminates a large number of odorants using precisely wired neural circuits. It offers an excellent opportunity to study mechanisms of neuronal wiring specificity at the single synapse level. Each olfactory receptor neuron typically expresses only one olfactory receptor from many receptor genes (1000 in mice). In mice, this striking singularity appears to be ensured by a...
متن کاملWiring Specificity: Axon–Dendrite Matching Refines the Olfactory Map
In Drosophila, about 50 classes of olfactory receptor neurons enter the brain where their axons form highly specific synapses with the dendrites of identified partner neurons. A recent study has shown that genetic manipulations that shift the position of one class of postsynaptic dendrites can cause an exact corresponding shift in the location of their partner axons.
متن کاملGenetic control of wiring specificity in the fly olfactory system.
Precise connections established between pre- and postsynaptic partners during development are essential for the proper function of the nervous system. The olfactory system detects a wide variety of odorants and processes the information in a precisely connected neural circuit. A common feature of the olfactory systems from insects to mammals is that the olfactory receptor neurons (ORNs) express...
متن کاملDevelopment of wiring specificity of the Drosophila olfactory system.
The central problem of neural circuit assembly is how wiring specificity is achieved. The Drosophila olfactory neural circuit presents a fascinating system to attack this problem. As in mammals, the Drosophila olfactory receptor neurons (ORNs) that express a given receptor converge their axons onto a common glomerulus in the antennal lobe, creating an odor map in this first olfactory structure ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00030-8